Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma

1 Oct 2024

Abstract excerpt

Oncogenic mutations (such as in KRAS) can dysregulate transcription and replication, leading to transcription-replication conflicts (TRCs). Here, we demonstrate that TRCs are enriched in human pancreatic ductal adenocarcinoma (PDAC) compared to other common solid tumors or normal cells. Several orthogonal approaches demonstrated that TRCs are oncogene dependent. A small interfering RNA (siRNA) screen identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39368091
DOI: 10.1016/j.celrep.2024.114820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinomaPMID 39368091Read ↗

Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Targeting DNA Damage Response and Replication Stress in Pancreatic CancerSemantic proximity Read ↗

Targeting the DNA damage response protein ATR kinase in pancreatic cancerSemantic proximity Read ↗

Targeting DNA Damage Response and Replication Stress in Pancreatic CancerSemantic proximity Read ↗

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stressSemantic proximity Read ↗

Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork CollapseSemantic proximity Read ↗

Inhibition of Non-Homologous End Joining Repair Impairs Pancreatic Cancer Growth and Enhances Radiation ResponseSemantic proximity Read ↗

Cytidine deaminase protects pancreatic cancer cells from replicative stress and drives resistance to DNA-targeting drugsSemantic proximity Read ↗

DNA polymerases in the risk and prognosis of colorectal and pancreatic cancers.Semantic proximity Read ↗

DNA Damage Repair Deficiency in Pancreatic Ductal Adenocarcinoma: Preclinical Models and Clinical PerspectivesSemantic proximity Read ↗

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.