Article

Combination of RUNX1 inhibitor and gemcitabine to mitigate chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2a-axis-mediated endoplasmic reticulum stress

2023-05-23

Abstract excerpt

<title>Abstract</title><p><bold>Background:</bold>Gemcitabine (GEM)-based chemotherapy is the standard treatment for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain largely unknown. RUNX1, a key transcription factor in hematopoiesis, also involved in the malignant progression of PDAC, but was unclear in the chemoresistance...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88e1e16a-3a36-59cf-a597-68fe871b904a
DOI: 10.21203/rs.3.rs-2944766/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combination of RUNX1 inhibitor and gemcitabine to mitigate chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2a-axis-mediated endoplasmic reticulum stressDOI 10.21203/rs.3.rs-2944766/v1Read

Integration of transcriptome and cistrome analysis identifies RUNX1-target genes involved in pancreatic cancer proliferationSemantic proximity Read

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancerSemantic proximity Read

Prognostic Model Identification of Ribosome Biogenesis-Related Genes in Pancreatic Cancer Based on Multiple Machine Learning AnalysesSemantic proximity Read

Impact of RUNX2 on drug-resistant human pancreatic cancer cells with p53 mutations.Semantic proximity Read

Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.Semantic proximity Read

Multidrug resistance genes screening of pancreatic cancer based on sensitivity profile to chemotherapeutic drugsSemantic proximity Read

Identification of chemoresistance‐related mRNAs based on gemcitabine‐resistant pancreatic cancer cell linesSemantic proximity Read

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistanceSemantic proximity Read

Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic CancerSemantic proximity Read

Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survivalSemantic proximity Read

SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axisSemantic proximity Read

eIF4G2-dependent translation restrains pancreatic cancer progressionSemantic proximity Read