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ITGA2 overexpression inhibits DNA repair and confers sensitivity to radiotherapies in pancreatic cancer

20 Aug 2022

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a 5-year survival rate of less than 10%, despite the recent advances in chemoradiotherapy. The sensitivity of the PDAC patients to chemoradiotherapy varies widely, especially to radiotherapy, suggesting the need for more elucidation of the underlying mechanisms. In this study, a novel function of the nuclear ITGA2, the alpha subunit of transmembrane...

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PMID: 35998796
DOI: 10.1016/j.canlet.2022.215855

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