Article

Base Excision Repair Pathway Regulates Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma

2023-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic mutations (such as in KRAS) can dysregulate transcription and replication leading to transcription conflicts (TRCs). Unresolved TRCs can cause lethal DNA damage. Here, we sought to investigate the oncogene dependency of TRCs and TRC regulatory pathways in pancreatic ductal adenocarcinoma (PDAC). Human PDAC demonstrated 30-120-fold higher levels of TRC genomic signatures compared to bre...

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Literature Corpus work: 9b6ae023-dab3-50e0-a512-1d05c8a03db7
DOI: 10.1101/2023.10.03.560510

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