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Article

Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus

1 May 2011

Abstract excerpt

Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely understood etiology. Recent evidence strongly supports an epigenetic contribution to the pathogenesis of lupus. To understand the extent and nature of dysregulated DNA methylation in lupus T cells, we performed a genome-wide DNA methylation study in CD4 (+) T cells in lupus patients compared to normal healthy controls. Cytosine...

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PMID: 21436623
DOI: 10.4161/epi.6.5.15374

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