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A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients

27 Oct 2020

Abstract excerpt

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 years of follow-up and across disease activity levels using 229 patient samples. We demonstrate that DNA methylation profiles in lupus are partly determined by ancestry-associated genetic variations and are highly stable over time. DNA...

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PMID: 33108347
DOI: 10.1172/jci.insight.143654

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