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DNA methylation of IFI44L as a potential blood biomarker for childhood-onset systemic lupus erythematosus

21 Mar 2024

Abstract excerpt

BACKGROUND: IFN-induced protein 44-like (IFI44L) promoter methylation has been demonstrated to serve as an effective blood diagnostic biomarker for adult-onset SLE. However, its utility as a diagnostic marker for childhood-onset SLE (cSLE) remains to be verified. METHODS: Initially, we conducted a differential analysis of gene methylation and mRNA expression patterns in cSLE whole blood samples obtained from the...

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PMID: 38514858
DOI: 10.1038/s41390-024-03135-1

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