Article

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

2024-05-21

Abstract excerpt

Fibrosing cholangiopathies, including biliary atresia and primary sclerosing cholangitis, involve immune-mediated bile duct epithelial injury and hepatic bile acid (BA) retention (cholestasis). Regulatory T-cells (Tregs) can prevent auto-reactive lymphocyte activation, yet the effects of BA on this CD4 lymphocyte subset are unknown. Gene regulatory networks for hepatic CD4 lymphocytes in a murine cholestasis model...

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Literature Corpus work: 4f76e614-89a8-55dc-a164-f554d27bbef0
DOI: 10.1101/2024.05.17.594680

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