Article

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

2022-10-25

Abstract excerpt

<h4>ABSTRACT</h4> Fibrosis is a physiological tissue repair mechanism, but excessive fibrosis can disrupt organ function. Alagille syndrome (ALGS), which is caused by mutations in the Notch ligand JAGGED1 , results in bile duct paucity, neonatal cholestasis, and a characteristic fibrotic response. Here, we show that Jag1 Ndr/Ndr mice, a model for ALGS, recapitulates ALGS-like pericellular fibrosis. Single-cell...

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Literature Corpus work: e0fc0ae2-16f0-5caa-be4f-905cfc840a51
DOI: 10.1101/2022.10.24.513578

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Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver FibrosisDOI 10.1101/2022.10.24.513578Read

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