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Article

Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis.

Journal of autoimmunity - 1 May 2015

Wang Yin-Hu, Yang Wei, Yang Jing-Bo, Jia Yan-Jie, Tang Wei, Gershwin M Eric, Ridgway William M, Lian Zhe-Xiong

Abstract excerpt

CD4(+)Foxp3(+) regulatory T cells (Tregs) play a non-redundant role in control of excessive immune responses, and defects in Tregs have been shown both in patients and murine models of primary biliary cirrhosis (PBC), a progressive autoimmune biliary disease. Herein, we took advantage of a murine model of PBC, the dominant negative transforming growth factor β receptor II (dnTGFβRII) mice, to assess Treg genetic...

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Identifiers

PMID: 25701076
DOI: 10.1016/j.jaut.2015.01.011
PMCID: PMC4829434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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