Article

24-Nor-ursodeoxycholic acid counteracts T <sub>H</sub> 17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T <sub>H</sub> 17 cells

2022-02-10

Abstract excerpt

<h4>Objective</h4> 24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating primary sclerosing cholangitis (PSC), an immune-mediated cholestatic liver disease. Since PSC strongly associates with inflammatory bowel diseases (IBD) driven by T H 17/Treg imbalance, we aimed to explore NorUDCA’s immunomodulatory potential on intestinal T H 17/Treg balance. <h4>Design</h4> NorUDCA’s impac...

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Literature Corpus work: 7fe45a23-3125-5bd6-8ba2-9c89bd94c512
DOI: 10.1101/2022.02.10.479975

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24-Nor-ursodeoxycholic acid counteracts T <sub>H</sub> 17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating T <sub>H</sub> 17 cellsDOI 10.1101/2022.02.10.479975Read

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