Article
Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells.
Clinical and experimental immunology - 1 Nov 2014
Tanaka H, Zhang W, Yang G-X, Ando Y, Tomiyama T, Tsuneyama K, Leung P, Coppel R L, Ansari A A, Lian Z X, Ridgway W M, Joh T, Gershwin M E
Abstract excerpt
Treatment of primary biliary cirrhosis (PBC) has lagged behind that of other autoimmune diseases. In this study we have addressed the potential utility of immunotherapy using regulatory T cells (Treg ) to treat murine autoimmune cholangitis. In particular, we have taken advantage of our ability to produce portal inflammation and bile duct cell loss by transfer of CD8(+) T cells from the dominant negative form of...
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