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Article

Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype.

The Journal of clinical investigation - 1 Nov 2011

Li Jun, Bessho Kazuhiko, Shivakumar Pranavkumar, Mourya Reena, Mohanty Sujit Kumar, Dos Santos Jorge L, Miura Irene K, Porta Gilda, Bezerra Jorge A

Abstract excerpt

Biliary atresia (BA) is a destructive cholangiopathy of childhood in which Th1 immunity has been mechanistically linked to the bile duct inflammation and obstruction that culminate in liver injury. Based on reports of decreased Th1 cytokines in some patients and the development of BA in mice lack...

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Identifiers

PMID: 22005305
DOI: 10.1172/JCI57728
PMCID: PMC3204839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22005305-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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