Article

Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes

2025-11-05

Abstract excerpt

The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiting our ability to target the aberrant cell growth typical of many Wnt-driven cancers. Here we focus on malignant liver tumors driven by activating CTNNB1 (β-catenin) mutations that nevertheless display distinct phenotypic states and Wnt outputs. By profiling patient-de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f5b72b3-106c-5141-84f5-a9ef90fb901e
DOI: 10.1101/2025.11.04.686471

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor PhenotypesDOI 10.1101/2025.11.04.686471Read

Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.Semantic proximity Read

Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencingSemantic proximity Read

Pan-cancer landscape of cancer-testis genes revealed by single-cell and spatial transcriptomicsSemantic proximity Read

Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and MedulloblastomaSemantic proximity Read

Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and MedulloblastomaSemantic proximity Read

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition.Semantic proximity Read

Functionally Coherent Transcription Factor Target Networks Illuminate Control of Epithelial RemodellingSemantic proximity Read

A WNT/β-catenin-associated transcriptional program predicts survival outcomes in patients with hepatocellular carcinoma.Semantic proximity Read

Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivitiesSemantic proximity Read

Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets.Semantic proximity Read

Wnt target genes and where to find themSemantic proximity Read

Enhancer pioneering activity of Wnt/β-catenin signalingSemantic proximity Read