Article
Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets.
Nucleic acids research - 1 Apr 2010
Weise Andreas, Bruser Katja, Elfert Susanne, Wallmen Britta, Wittel Yvonne, Wöhrle Simon, Hecht Andreas
Abstract excerpt
Alternative splicing can produce multiple protein products with variable domain composition from a single gene. The mouse Tcf7l2 gene is subject to alternative splicing. It encodes TCF4, a member of the T-cell factor (TCF) family of DNA-binding proteins and a nuclear interaction partner of beta-catenin which performs essential functions in Wnt growth factor signalling. Multiple TCF4 isoforms, potentially...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.