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Genome-wide profiling of transcription factor activity in primary liver cancer using single-cell ATAC sequencing

1 Nov 2023

Abstract excerpt

Primary liver cancer (PLC) consists of two main histological subtypes; hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). The role of transcription factors (TFs) in malignant hepatobiliary lineage commitment between HCC and iCCA remains underexplored. Here, we present genome-wide profiling of transcription regulatory elements of 16 PLC patients using single-cell assay for transposase...

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PMID: 37980571
DOI: 10.1016/j.celrep.2023.113446

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