Article

Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma

2024-12-06

Abstract excerpt

(1) Background: Hepatoblastoma and medulloblastoma are two types of pediatric tumors with embryonic origins. Both tumor types can exhibit genetic alterations that affect beta-catenin and Wnt pathway; (2) Materials and Methods: This study used bioinformatics and integrative analysis of multi-omics data at both the tumor and single-cell levels to investigate these two distinct pediatric tumors: medulloblastoma and h...

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Literature Corpus work: 761269dc-d094-52f3-89ee-c0d7b00bdc0a
DOI: 10.20944/preprints202412.0630.v1

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