A WNT/β-catenin-associated transcriptional program predicts survival outcomes in patients with hepatocellular carcinoma.

doi:10.1016/j.yexmp.2026.105049

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Article

A WNT/β-catenin-associated transcriptional program predicts survival outcomes in patients with hepatocellular carcinoma.

Experimental and molecular pathology - 1 Jun 2026

Scalera Stefano, Cipriani Laura, Scarinci Andrea, Schiavoni Giulia, Fanciulli Maurizio, Ciuffreda Ludovica, De Nicola Francesca, Goeman Frauke, Pescarmona Edoardo, Diodoro Mariagrazia, Melucci Elisa, Gallo Enzo, Vici Patrizia, Pizzuti Laura, Barba Maddalena, Krasniqi Eriseld, Dell'Aquila Emanuela, Manai Chiara, Paoletti Giancarlo, Cappuzzo Federico, Zeuli Massimo, Ciliberto Gennaro, Perri Pasquale, Grazi Gian Luca, Bon Giulia, Maugeri-Saccà Marcello

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common form of liver cancer and a major cause of cancer-related deaths worldwide. Despite the wealth of genomics data, treatment and prognosis are still dependent on clinical and pathological factors. The molecular heterogeneity characterizing HCC is denoted by the different etiology and the related array of signaling pathways involved in tumor initiation and...

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PMID: 42114450
DOI: 10.1016/j.yexmp.2026.105049

Genes

CTNNB1

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