Article

Pan-cancer landscape of cancer-testis genes revealed by single-cell and spatial transcriptomics

2025-08-29

Abstract excerpt

Cancer-testis genes (CTGs) are attractive immunotherapeutic targets owing to their restricted testicular expression and aberrant activation in cancers. However, their regulatory mechanisms, spatial organization, and clinical utility remain incompletely understood. Here, we leveraged large-scale single-cell and spatial transcriptomic data to perform a comprehensive pan-cancer analysis of CTGs. We established a high...

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Literature Corpus work: acc174f2-e23b-59f2-bb58-ceb595825e70
DOI: 10.1101/2025.08.25.672079

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