Article

Functionally Coherent Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling

2018-10-29

Abstract excerpt

<h4>Summary</h4> Cell identity is governed by gene expression, regulated by Transcription Factor (TF) binding at cis-regulatory modules. We developed the NetNC software to decode the relationship between TF binding and the regulation of cognate target genes in cell decision-making; demonstrated on nine datasets for the Snail and Twist TFs, and also modENCODE ‘HOT’ regions. Results illuminated conserved molecular...

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Literature Corpus work: c5f5e9a1-9db9-5ab3-a271-7759f83050af
DOI: 10.1101/455709

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