Article
Differential Wnt/β-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2026
Kluiver Thomas A, Nordin Anna, Lu Yuyan, Guo Xuan, Schubert Stephanie A, Yeung Darien, Ardisasmita Arif Ibrahim, Terpstra Wessel, Zhang Chang, Duan Xiaochen, Savur Rishi, van den Heuvel Marius C, de Meijer Vincent E, de Kleine Ruben H, Kraal Kathelijne, de Krijger Ronald R, Zsiros József, Cantù Claudio, Peng Weng Chuan
Abstract excerpt
The mechanisms by which Wnt/β-catenin signaling regulates gene expression in a tissue- and context-specific manner remain poorly understood, limiting our ability to target the aberrant cell growth typical of many Wnt-driven cancers. Here, we focus on malignant liver tumors driven by activating CTNNB1 (β-catenin) mutations that nevertheless display distinct phenotypic states and Wnt outputs. By profiling...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.