Article
The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition.
Nucleic acids research - 16 Dec 2014
Hoverter Nate P, Zeller Michael D, McQuade Miriam M, Garibaldi Angela, Busch Anke, Selwan Elizabeth M, Hertel Klemens J, Baldi Pierre, Waterman Marian L
Abstract excerpt
LEF/TCFs direct the final step in Wnt/β-catenin signalling by recruiting β-catenin to genes for activation of transcription. Ancient, non-vertebrate TCFs contain two DNA binding domains, a High Mobility Group box for recognition of the Wnt Response Element (WRE; 5'-CTTTGWWS-3') and the C-clamp domain for recognition of the GC-rich Helper motif (5'-RCCGCC-3'). Two vertebrate TCFs (TCF-1/TCF7 and TCF-4/TCF7L2) use...
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