Article

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in <i>SMARCAL1</i>

2024-02-02

Abstract excerpt

<h4>ABSTRACT</h4> Most of the human cancers are dependent on telomerase to extend the telomeres. But ∼10% of all cancers use a telomerase-independent, homologous recombination mediated pathway called alternative lengthening of telomeres (ALT). Due to poor prognosis, the ALT status is not being considered yet in the diagnosis of cancer. No such specific treatment is available till date for ALT cancers. ALT positiv...

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Literature Corpus work: 422526aa-ef41-5c8f-ac83-5115ba2d4d43
DOI: 10.1101/2024.02.01.578345

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