Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinoma

1 May 2020

Abstract excerpt

Abstract The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex. Most of these mutations are loss-of-function mutations, which disrupt critical functions in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34316685
DOI: 10.1093/narcan/zcaa005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMARCA4 deficiency-associated heterochromatin induces intrinsic DNA replication stress and susceptibility to ATR inhibition in lung adenocarcinomaPMID 34316685Read ↗

The role of SMARCA4 in lung cancerSemantic proximity Read ↗

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation HotspotsSemantic proximity Read ↗

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.Semantic proximity Read ↗

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR DependencySemantic proximity Read ↗

Defective replication stress response inhibits lymphomagenesis and impairs lymphocyte reconstitution.Semantic proximity Read ↗

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity.Semantic proximity Read ↗

Slx4 and Fun30/SMARCAD1 coordinate S-phase checkpoint regulation and replication fork protection in response to Top1-DNA crosslinksSemantic proximity Read ↗

SMARCAL1: a DNA repair protein recruited to double-strand breaks at stalled replication forks to promote genome stability through a homologous recombination pathwaySemantic proximity Read ↗

Identification of SMARCAL1 as a component of the DNA damage response.Semantic proximity Read ↗

A Critical Review of the Impact of SMARCA4 Mutations on Survival Outcomes in Non-Small Cell Lung CancerSemantic proximity Read ↗

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.Semantic proximity Read ↗

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.