Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability

1 Feb 2024

Abstract excerpt

R-loops are three-stranded structures that can pose threats to genome stability. RNase H1 precisely recognizes R-loops to drive their resolution within the genome, but the underlying mechanism is unclear. Here, we report that ARID1A recognizes R-loops with high affinity in an ATM-dependent manner. ARID1A recruits METTL3 and METTL14 to the R-loop, leading to the m6A methylation of R-loop RNA. This m6A modification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Remodeling and Cancer
Share to Peptidase Inhibition and Analysis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38358891
DOI: 10.1016/j.celrep.2024.113779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stabilityPMID 38358891Read ↗

ARID1A regulates DNA repair through chromatin organization and its deficiency triggers DNA damage-mediated anti-tumor immune responseSemantic proximity Read ↗

SMARCAD1 Regulates R-Loops at Active Replication Forks Linked to Cancer Mutation HotspotsSemantic proximity Read ↗

Targeting Noncanonical TEAD Axis to Overcome DNA Repair-Driven ChemoresistanceSemantic proximity Read ↗

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP InhibitorsSemantic proximity Read ↗

ARID1A regulates R-loop associated DNA replication stressSemantic proximity Read ↗

ARID1A regulates R-loop associated DNA replication stressSemantic proximity Read ↗

BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.Semantic proximity Read ↗

ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian CancerSemantic proximity Read ↗

ARID1B promotes DNA end resection via MDC1 and co-transactivation of DNA repair genes with c-MYC in small cell lung cancerSemantic proximity Read ↗

ADAR1 Prevents R-loop Accumulation-Driven ATR Pathway Activation in Ovarian CancerSemantic proximity Read ↗

Site-specific N6-methyladenosine fine tunes CTCF/cohesin-defined enhancer-promoter interactions and oncogenic transcription programSemantic proximity Read ↗

ARID1A and Its Impact Across the Hallmarks of CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.