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Advances in understanding DNA processing and protection at stalled replication forks

22 Jan 2019

Abstract excerpt

The replisome, the molecular machine dedicated to copying DNA, encounters a variety of obstacles during S phase. Without a proper response to this replication stress, the genome becomes unstable, leading to disease, including cancer. The immediate response is localized to the stalled replisome and includes protection of the nascent DNA. A number of recent studies have provided insight into the factors recruited...

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PMID: 30670471
DOI: 10.1083/jcb.201809012

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