PARADYS: Patient-specific Ranking of Genes Driving Dysregulation in Cancer and Therapeutic Implications

Abstract excerpt

In cancer, most somatic mutation are so-called passenger mutations with no functional impact on disease development. Only a subset of the mutations act as drivers and are responsible for tumor growth and progression. Identifying patient-specific driver mutations is one of the main challenges in precision oncology. Existing computational methods to identify patient-specific cancer drivers either integrate mutation...

Topics

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• Cohort Studies
• Computer Simulation
• Databases, Genetic
• Genes, Neoplasm
• Neoplasms
• Reproducibility of Results
• ROC Curve
• Support Vector Machine

Identifiers and source

Literature Corpus work

4f3264e0-85c4-52e7-bb73-df45822ff555

DOI

10.22541/au.171837029.95112230/v1