Article

Pan-Cancer Driver Mutation Signatures Define a Molecular Taxonomy of Tumors

2026-06-18

Abstract excerpt

Cancers with similar histology often exhibit divergent clinical behavior, reflecting molecular heterogeneity not captured by current classification systems. Although driver mutations are central to tumorigenesis, their broader systems-level consequences have not been systematically leveraged. We integrated genomic and transcriptomic data across cancers to define driver mutation signatures (DMS), coordinated transc...

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Literature Corpus work: a6ae242e-811b-5930-9fc4-5d119685905a
DOI: 10.64898/2026.06.17.732825

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