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Graph convolution networks model identifies and quantifies gene and cancer specific transcriptome signatures of cancer driver events.

Computers in biology and medicine - 1 Feb 2025

Ben Cohen Gil, Yaacov Adar, Ben Zvi Yishai, Loutati Ranel, Lishinsky Natan, Landau Jakob, Hope Tom, Popovzter Aron, Rosenberg Shai

Abstract excerpt

BACKGROUND: The identification and drug targeting of cancer causing (driver) genetic alterations has seen immense improvement in recent years, with many new targeted therapies developed. However, identifying, prioritizing, and treating genetic alterations is insufficient for most cancer patients. Current clinical practices rely mainly on DNA level mutational analyses, which in many cases fail to identify...

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PMID: 39700860
DOI: 10.1016/j.compbiomed.2024.109491

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