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Article

Differential effects of zinc on functionally distinct human growth hormone mutations.

Protein engineering - 1 Jul 2003

Duda K M, Brooks C L

Abstract excerpt

Human growth hormone (hGH) binds and activates lactogenic receptors by a sequential receptor dimerization mechanism. The affinity for the first lactogenic receptor is increased due to one zinc molecule linking hGH residues H18 and E174, located in helices 1 and 4, respectively, with two adjacent...

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Identifiers

PMID: 12915731
DOI: 10.1093/protein/gzg067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12915731-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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