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Article

Engineering an interfacial zinc site to increase hormone-receptor affinity.

Chemistry & biology - 1 Sept 1994

Matthews D J, Wells J A

Abstract excerpt

BACKGROUND: Human growth hormone (hGH) binds to both the hGH and human prolactin (hPRL) receptors. Binding to the hPRL receptor, however, is approximately 50-fold tighter and requires a single Zn2+ cation, unlike binding of hGH to the hGH receptor. Previous mutational studies have identified putative ligands from hGH and the hPRL receptor responsible for coordinating the interfacial Zn2+. RESULTS: One of these...

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PMID: 9383367
DOI: 10.1016/1074-5521(94)90037-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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