Article

Characterisation of transgenic tobacco plants expressing synthetic mouse prion protein

2016-01-01

Abstract excerpt

The cellular prion protein (PrPC) is a glycoprotein with unknown function constitutively expressed in mammalian neurons. PrPC converts to a pathogenic misfolded isomer (PrPSc) through a poorly understood process, resulting in a group of fatal neurodegenerative diseases collectively known as transmissible spongiform encephalopathy or prion disease. Elucidating the molecular mechanisms behind prion conversion requir...

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Literature Corpus work: 4ed928db-f89a-5b95-ab9a-8cf665a20b04
DOI: 10.15123/pub.5838

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