Article
Transgenetic investigations of prion diseases of humans and animals.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Feb 1993
Prusiner S B
Abstract excerpt
Prions cause transmissible and genetic neurodegenerative diseases. Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrPSc), which is encoded by a chromosomal gene. Although the PrP gene is single copy, transgenic mice with both alleles...
Topics
- Animals
- Cattle
- Cattle Diseases
- Gene Expression
- Genetic Variation
- Humans
- Mice
- Mice, Transgenic
- Mutation
- PrPSc Proteins
- Prion Diseases
- Prions
- Protein Processing, Post-Translational
- Sheep
- Sheep Diseases