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Article

Pathogenic human prion protein rescues PrP null phenotype in transgenic mice.

Neuroscience letters - 22 Apr 2004

Asante Emmanuel A, Li Yuan-Gen, Gowland Ian, Jefferys John G R, Collinge John

Abstract excerpt

Infectious prion diseases may be acquired, sporadic or inherited in their aetiology. Inherited prion diseases are caused by coding mutations in the prion protein (PrP) gene. We investigated whether one of the commonest of these mutations, E200K, results in a functionally inactive prion protein by expressing human PrP 200K in transgenic mice homozygous for murine PrP null alleles. We examined the intrinsic...

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Identifiers

PMID: 15082172
DOI: 10.1016/j.neulet.2004.01.049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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