Article

Development and characterisation of PC12 cell lines allowing inducible expression of prion proteins carrying pathogenic mutations

2005-01-01

Abstract excerpt

Inherited prion diseases are linked to mutations in the prion protein (PrP)p gene that are presumed to favor conversion of PrP into a neurotoxic isoform (PrpSc) Several cellular models of inherited prion diseases have been Q developed in which mutant PrP costitutively expressed acquires PrPSc-like properties but is not cytotoxic. However, the use of constitutive models does not exclude the po...

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Literature Corpus work: 81a76283-3524-5c62-a858-43e6465a49f7
DOI: 10.21954/ou.ro.000101c0

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