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Article

Inhibition of PrPSc formation by lentiviral gene transfer of PrP containing dominant negative mutations.

Journal of cell science - 1 Nov 2004

Crozet Carole, Lin Yea-Lih, Mettling Clément, Mourton-Gilles Chantal, Corbeau Pierre, Lehmann Sylvain, Perrier Véronique

Abstract excerpt

Currently, there is no treatment to cure transmissible spongiform encephalopathies. By taking advantage of the 'prion-resistant' polymorphisms Q171R and E219K that naturally exist in sheep and humans, respectively, we have evaluated a therapeutic approach of lentiviral gene transfer. Here, we show that VSV-G (vesicular stomatitis virus G glycoprotein) pseudotyped FIV-(feline immunodeficiency virus) derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15494372
DOI: 10.1242/jcs.01484
PMCID: PMC2062426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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