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Article

Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Mar 2005

Stewart Richard S, Piccardo Pedro, Ghetti Bernardino, Harris David A

Abstract excerpt

Although PrP(Sc) is thought to be the infectious form of the prion protein, it may not be the form that is responsible for neuronal cell death in prion diseases. (Ctm)PrP is a transmembrane version of the prion protein that has been proposed to be a neurotoxic intermediate underlying prion-induced pathogenesis. To investigate this hypothesis, we have constructed transgenic mice that express L9R-3AV PrP, a mutant...

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Identifiers

PMID: 15800202
DOI: 10.1523/JNEUROSCI.0105-05.2005
PMCID: PMC6724892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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