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Article

PrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prions.

Acta neuropathologica - 1 Oct 2016

Barron Rona M, King Declan, Jeffrey Martin, McGovern Gillian, Agarwal Sonya, Gill Andrew C, Piccardo Pedro

Abstract excerpt

Mammalian prions are unusual infectious agents, as they are thought to consist solely of aggregates of misfolded prion protein (PrP). Generation of synthetic prions, composed of recombinant PrP (recPrP) refolded into fibrils, has been utilised to address whether PrP aggregates are, indeed, infectious prions. In several reports, neurological disease similar to transmissible spongiform encephalopathy (TSE) has been...

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Identifiers

PMID: 27376534
DOI: 10.1007/s00401-016-1594-5
PMCID: PMC5023723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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