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Article

GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice.

Neurobiology of disease - 1 Aug 2004

Barmada Sami, Piccardo Pedro, Yamaguchi Keiji, Ghetti Bernardino, Harris David A

Abstract excerpt

Prion diseases result from conversion of PrPC, a neuronal membrane glycoprotein of unknown function, into PrPSc, an abnormal conformer that is thought to be infectious. To facilitate analysis of PrP distribution in the brain, we have generated transgenic mice in which a PrP promoter drives expression of PrP-EGFP, a fusion protein consisting of enhanced green fluorescent protein inserted adjacent to the glycolipid...

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Identifiers

PMID: 15262264
DOI: 10.1016/j.nbd.2004.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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