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Article

Loss of prion protein in a transgenic model of amyotrophic lateral sclerosis.

Molecular and cellular neurosciences - 1 Feb 2002

Dupuis Luc, Mbebi Corinne, Gonzalez de Aguilar José-Luis, Rene Frédérique, Muller André, de Tapia Marc, Loeffler Jean-Philippe

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a motor neuron degenerative disorder caused in a proportion of cases by missense mutations in the gene encoding Cu/Zn superoxide dismutase (Cu/Zn-SOD) which result in unknown, lethal enzymatic activity. Based on a differential screening approach, we show here that the gene encoding the cellular prion protein (PrP(C)) was specifically repressed in a transgenic model of ALS...

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Identifiers

PMID: 11860274
DOI: 10.1006/mcne.2001.1049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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