Article

Allele imputation for the Killer cell Immunoglobulin-like Receptor KIR3DL1/S1

2021-05-13

Abstract excerpt

Highly polymorphic interactions of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects severity of infections, immune-mediated diseases, and some cancers, and impacts the course of cancer treatment, including transplantation. KIR3DL1 is an inhibitory receptor, and KIR3DS1 is an activating receptor...

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Literature Corpus work: 4e97d0f1-71e1-5ead-8c79-a2ed8219dbc4
DOI: 10.1101/2021.05.13.443975

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