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Article

Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1.

PLoS computational biology - 1 Feb 2022

Harrison Genelle F, Leaton Laura Ann, Harrison Erica A, Kichula Katherine M, Viken Marte K, Shortt Jonathan, Gignoux Christopher R, Lie Benedicte A, Vukcevic Damjan, Leslie Stephen, Norman Paul J

Abstract excerpt

Highly polymorphic interaction of KIR3DL1 and KIR3DS1 with HLA class I ligands modulates the effector functions of natural killer (NK) cells and some T cells. This genetically determined diversity affects severity of infections, immune-mediated diseases, and some cancers, and impacts the course of immunotherapies, including transplantation. KIR3DL1 is an inhibitory receptor, and KIR3DS1 is an activating receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35192601
DOI: 10.1371/journal.pcbi.1009059
PMCID: PMC8896733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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