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Article

Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.

Genome research - 1 Jun 2023

Song Li, Bai Gali, Liu X Shirley, Li Bo, Li Heng

Abstract excerpt

Killer cell immunoglobulin like receptor (KIR) genes and human leukocyte antigen (HLA) genes play important roles in innate and adaptive immunity. They are highly polymorphic and cannot be genotyped with standard variant calling pipelines. Compared with HLA genes, many KIR genes are similar to each other in sequences and may be absent in the chromosomes. Therefore, although many tools have been developed to...

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PMID: 37169596
DOI: 10.1101/gr.277585.122
PMCID: PMC10519407

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