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Article

Engineering B cells to express fully customizable antibodies with enhanced Fc functions.

Nature communications - 13 May 2026

Huang Chun, Mathur Atishay, Chang Chan-Hua, Huang Xiaoli, Chen Hsu-Yu, Davis Zachary B, O'Dell Karla, Shuman Elizabeth A, Kung Raymond W, Rogers Geoffrey L, Cannon Paula M

Abstract excerpt

Genome editing within the constant region of the immunoglobulin Heavy chain locus (IGH) can reprogram B cells to express heavy-chain-only antibodies (HCAbs) containing custom antigen-recognition domains. HCAb-engineered cells express both surface B cell receptor (BCR) and secreted antibody isoforms and respond to antigen. Here, we extend this approach to also allow customization of the constant (Fc) domain of the...

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Share to B-Lymphocytes
Share to IGH gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Immunoglobulin Fc Fragments

Share to Immunoglobulin Heavy Chains

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Share to Protein Engineering

Share to Receptors, Antigen, B-Cell

Source

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Identifiers

PMID: 42129193
DOI: 10.1038/s41467-026-72991-8
PMCID: PMC13377122

Genes

IGH
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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