Design of Antigen-Specific Antibody CDRH3 Sequences Using AI and Germline-Based Templates

Abstract excerpt

<h4>ABSTRACT</h4> Antibody-antigen specificity is engendered and refined through a number of complex B cell processes, including germline gene recombination and somatic hypermutation. Here, we present an AI-based technology for de novo generation of antigen-specific antibody CDRH3 sequences using germline-based templates, and validate this technology through the generation of antibodies against SARS-CoV-2. AI-bas...

Topics

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• Antibodies, Neutralizing
• Complementarity Determining Regions
• Epitopes, T-Lymphocyte
• Immune Cell Function and Interaction
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Single-Chain Antibodies
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

8e8d9ef7-b46c-577c-b11a-419aee70956a

DOI

10.1101/2024.03.22.586241