Article

Suppression of the JAK/STAT Pathway Inhibits Neuroinflammation in the Line 61-PFF Mouse Model of Parkinson’s Disease

2024-05-07

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is characterized by neuroinflammation, progressive loss of dopaminergic neurons, and accumulation of a-synuclein (a-Syn) into insoluble aggregates called Lewy pathology. The Line 61 a-Syn mouse is an established preclinical model of PD; Thy-1 is used to promote human a-Syn expression, and features of sporadic PD develop at 9-18 months of age. To accelerate the P...

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Literature Corpus work: 4e79544b-39a6-5433-b24b-6650cdae90a4
DOI: 10.21203/rs.3.rs-4307273/v1

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