Article

Inhibition of de novo ceramide synthesis mitigates alpha-synuclein pathology and restores cognitive function in a Parkinson's disease mouse model

2025-08-01

Abstract excerpt

<title>Abstract</title> Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of α-synuclein aggregates, yet no disease-modifying therapies currently exist. Ceramide metabolism is increasingly implicated in protein aggregation and mitochondrial dysfunction, both of which are prevalent in neurodegenerative disorders. While pri...

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Literature Corpus work: 87d9acd5-6ed9-56f5-8b77-e2332e0a76f2
DOI: 10.21203/rs.3.rs-7167930/v1

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