Article

Inhibition of T cell infiltration and soluble TNF signaling is neuroprotective in the alpha-synuclein overexpressing mouse model of Parkinson’s disease

2025-04-25

Abstract excerpt

<title>Abstract</title> <p> Modulation of the neuroinflammatory response is emerging as an interesting approach for the treatment of Parkinson´s disease (PD). In this study we have used an adeno-associated virus (AAV9) to overexpress alpha-synuclein (αSyn) in the substantia nigra pars compacta of mice to induce a dose-dependent neuronal loss. Our results show that αSyn overexpression induces CD4 <sup>+</sup> T...

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Literature Corpus work: 6c9d48ff-6fb8-56f4-bfd6-93378748b3ba
DOI: 10.21203/rs.3.rs-6252707/v1

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