Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's Disease

25 Apr 2025

Abstract excerpt

There is increasing interest in developing therapeutic interventions aimed at preventing neuroinflammation in Parkinson's disease (PD). However, the specific characteristics of inflammation across different cell types and the underlying mechanisms of PD-related inflammation remain inadequately understood. In this study, we conducted an analysis of single-cell RNA sequencing (scRNA-seq) and microarray data derived...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40285838
DOI: 10.1007/s10753-025-02306-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated Analysis of Single-Cell and Transcriptome Data Reveals the Role and Regulatory Mechanisms of Neuroinflammation in Parkinson's DiseasePMID 40285838Read ↗

Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway.Semantic proximity Read ↗

Multi-omic landscaping of human midbrains identifies neuroinflammation as major disease mechanism in advanced-stage Parkinson’s diseaseSemantic proximity Read ↗

Multi-Omics Profiling Identifies Neuroinflammation-Related Genes and Exosomal miRNA as Robust Diagnostic Signatures for Parkinson's DiseaseSemantic proximity Read ↗

Glial multicellular programs reveal distinct patient stratification in Parkinson's diseaseSemantic proximity Read ↗

A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's diseaseSemantic proximity Read ↗

Integrative analysis of gene expression profiles of substantia nigra identifies potential diagnosis biomarkers in Parkinson's diseaseSemantic proximity Read ↗

Differential gene expression and immune profiling in Parkinson’s disease: unveiling potential candidate biomarkersSemantic proximity Read ↗

Integrative Analysis of Gene Expression Profiles of Substantia Nigra Identifies Potential Diagnosis Biomarkers in Parkinson's diseaseSemantic proximity Read ↗

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissueSemantic proximity Read ↗

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissueSemantic proximity Read ↗

Single-nucleus and spatial transcriptomic analysis identified molecular features of neuronal heterogeneity and distinct glial responses in Parkinson’s diseaseSemantic proximity Read ↗

Single-nucleus and spatial transcriptomic analysis identified molecular features of neuronal heterogeneity and distinct glial responses in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.