Article

IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy

2022-11-23

Abstract excerpt

Multiple system atrophy (MSA) is a rare and fatal synucleinopathy characterized by insoluble alpha-synuclein (α-syn) cytoplasmic inclusions located within oligodendroglia. Neuroinflammation, demyelination, and neurodegeneration are correlated with areas of GCI pathology, however it is not known what specifically drives disease pathogenesis. Recently in a mouse model of MSA, CD4+ T cells have been shown to drive ne...

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Literature Corpus work: 3d2fccdb-1cee-59aa-8f2e-e516780af66f
DOI: 10.1101/2022.11.22.517543

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